Arne Schousboe
Short CV
Arne Schousboe, Professor, D.Sc.
Employment: Since 1990 Professor at the Danish University of Pharmaceutical Sciences (from Jan 2007 the Faculty of Pharmaceutical Sciences, University of Copenhagen)
External funding: Danish Medical Research Council, Lundbeck Foundation, Hørslev Foundation
Research profile: The major research areas include studies of metabolism, transport and receptor interactions of the neurotransmitters glutamate and GABA. Most studies are performed using primary cultures of neurons and astrocytes. In addition expression systems, e.g. Xenopus oocytes and cell lines may be used to study the molecular properties of receptors.
Recent publications (2006)
Waagepetersen, H.S., Hansen, G.H., Fenger, K., Lindsay, J.G., Gibson, G. and Schousboe, A. Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of α-ketoglutarate dehydrogenase. Glia 53, 225-231 (2006).
McKenna, M.C., Waagepetersen, H.S., Schousboe, A. and Sonnewald, U. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: Current evidence and pharmacological tools. Biochem. Pharmacol. 71, 399-306 (2006).
Sonnewald, U., Syversen, T., Schousboe, A., Waagepetersen, H.S. and Aschner, M. Actions of toxins on cerebral metabolism at the cellular level. In: Handbook of Neurochem. and Molec. Neurobiol., 3rd ed. (A. Lajtha et al., eds.). Springer Publ., NY (2006) in press.
Schousboe, A. and Waagepetersen, H.S. GABA neurotransmission: An overview. In: Handbook of Neurochem. and Molec. Neurobiol., 3rd ed. (A. Lajtha et al., eds.). Springer Publ., NY (2006) in press.
Clausen, R.P., Madsen, K., Larsson, O.M., Frølund, B., Krogsgaard-Larsen, P. and Schousboe, A. Structure-activity relationship and pharmacology of γ-aminobutyric acid (GABA) transport inhibitors. Adv. Pharmacol. 2006, in press.
Madsen, K.B., Larsson, O.M. and Schousboe, A. Regulation of excitation by GABA neurotransmission: Focus on metabolism and transport. In: Inhibitory Regulation of Excitatory Neurotransmission (Darlison, M., ed.). Springer Verlag, Berlin (2006) in press.
Gether, U., Andersen, P.H., Larsson, O.M. and Schousboe, A. Neurotransmitter transporters: Molecular function of important drug targets. Trends in Pharmacol. Sci. (2006) in press.
Clausen, R.P., Frølund, B., Larsson, O.M., Schousboe, A., Krogsgaard-Larsen, P. and White, H.S. A novel selective β-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS. Neurochem. Int. 48, 637-642 (2006).
Bak, L.K., Schousboe, A., Sonnewald, U. and Waagepetersen, H.S. Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons. J. Cereb. Blood Flow Metab. (2006) in press.
Poulsen, C.F., Schousboe, I., Sarup, A., White, H.S. and Schousboe, A. Effect of topiramate and dBcAMP on expression of the glutamate transporters. Neurochem. Int. 48, 657-661 (2006).
Sonnewald, U., Kortner, T.M., Qu, H., Olstad, E., Sunol, C., Bak, L.K., Schousboe, A. and Waagepetersen, H. Demonstration of extensive GABA synthesis in a small population of GAD positive neurons in cerebellare cultures by the use of pharmacological tools. Neurochem. Int. 48, 572-578 (2006).
Albrecht, J., Sonnewald, U., Waagepetersen, H.S. and Schousboe, A. Glutamine in the central nervous system function and dysfunction. Front. Biosci. (2006) in press.
Schousboe, A. and Waagepetersen, H.S. Glial modulation of GABAergic and glutamatergic neurotransmission. Curr. Topics Med. Chem. (2006) in press.
Kasper, C., Pickering, D.S., Mirza, O., Olsen, L., Kristensen, A.S., Greenwood, J., Liljefors, T., Schousboe, A., Wätjen, F., Gajhede, M., Sigurskjold, B.W. and Kastrup, J.S. The structure of a mixed GluR2 ligand-binding core dimmer in complex with (S)-glutamate and the antagonist (S)-NS1209. J. Mol. Biol. 357, 1184-1201(2006).
